Interactions between the receptors for platelet-derived growth factor and epidermal growth factor.
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Interactions between the receptors for platelet-derived growth factor and epidermal growth factor
Preincubation of Swiss 3T3 cells or human fibroblasts with purified platelet-derived growth factor (PDGF) at 4 degrees C or 37 degrees C rapidly inhibits subsequent binding of 125I-epidermal growth factor (125I-EGF). The effect does not result from competition by PDGF for binding to the EGF receptor since (a) very low concentrations of PDGF are effective, (b) cells with EGF receptors but no PDG...
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Platelet-derived growth factor (PDGF) is a connective tissue cell mitogen that originally was purified from human platelets, but recently has been found to be produced by many different cell types (reviewed by Ross et al. 1986; Heldin and Westermark, 1989). The in vivo function of PDGF remains speculative, but the fact that PDGF is released by platelets and by cells involved in the inflammatory...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1983
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.96.3.679